Prague Airport is located 10 km to the west of Prague.
| Destination | Airline |
|---|
| Austria |
| | Vienna | Germanwings |
| Belgium |
| | Brussels | Brussels Airlines, Wizz Air |
| Bulgaria |
| | Burgas | SmartWings, Wizz Air |
| Croatia |
| | Dubrovnik | Germanwings |
| | Split | Germanwings, SmartWings |
| | Zadar | Germanwings |
| Denmark |
| | Aalborg | Cimber Sterling, Norwegian |
| | Århus | Cimber Sterling |
| | Billund | Cimber Sterling, Norwegian |
| | Copenhagen | Brussels Airlines, Cimber Sterling, Norwegian |
| | Rønne | Cimber Sterling |
| | Sønderborg | Cimber Sterling |
| | Viborg | Cimber Sterling, Norwegian |
| England |
| | Birmingham | Bmibaby, Brussels Airlines, Ryanair |
| | Bristol | Brussels Airlines, Easyjet |
| | Leeds | Brussels Airlines, Jet2 |
| | Liverpool | Wizz Air |
| | London | Brussels Airlines, Easyjet, Germanwings, Wizz Air |
| | Manchester | Bmibaby, Brussels Airlines, Jet2 |
| | Newcastle | Brussels Airlines |
| | Nottingham | Bmibaby, Brussels Airlines, Easyjet |
| Finland |
| | Helsinki | Brussels Airlines |
| France |
| | Lyon | Brussels Airlines |
| | Marseille | Brussels Airlines |
| | Nice | Brussels Airlines, Germanwings |
| | Paris | Brussels Airlines, SmartWings, Wizz Air |
| | Strasbourg | Brussels Airlines |
| | Toulouse | Brussels Airlines |
| Germany |
| | Berlin | Brussels Airlines, Germanwings |
| | Cologne | Germanwings |
| | Dresden | Germanwings |
| | Frankfurt | Brussels Airlines, Ryanair |
| | Hamburg | Brussels Airlines, Germanwings |
| | Leipzig | Germanwings |
| | Munich | Brussels Airlines, Germanwings |
| | Rostock | Germanwings |
| Greece |
| | Athens | Brussels Airlines |
| | Thessaloniki | Germanwings |
| Hungary |
| | Budapest | Brussels Airlines, Germanwings |
| Italy |
| | Bari | Wizz Air |
| | Bologna | Brussels Airlines, Wind Jet |
| | Cagliari | SmartWings |
| | Catania | Brussels Airlines, SmartWings, Wind Jet |
| | Florence | Brussels Airlines |
| | Milan | Brussels Airlines, Germanwings, SmartWings, Wizz Air |
| | Naples | Brussels Airlines, SmartWings, Wizz Air |
| | Olbia | SmartWings |
| | Palermo | Wind Jet |
| | Rome | Brussels Airlines, Germanwings, SmartWings, Wizz Air |
| | Treviso | Germanwings, Wizz Air |
| | Turin | Brussels Airlines |
| | Venice | Brussels Airlines |
| | Verona | Germanwings |
| Morocco |
| | Casablanca | Brussels Airlines |
| Netherlands |
| | Eindhoven | Wizz Air |
| Northern Ireland |
| | Belfast | Bmibaby |
| Norway |
| | Ålesund | Norwegian |
| | Bardufoss | Norwegian |
| | Bergen | Norwegian |
| | Bodø | Norwegian |
| | Haugesund | Norwegian |
| | Kristiansand | Norwegian |
| | Molde | Norwegian |
| | Narvik | Norwegian |
| | Oslo | Brussels Airlines, Norwegian, Wizz Air |
| | Stavanger | Norwegian |
| | Tromsø | Norwegian |
| | Trondheim | Norwegian |
| Poland |
| | Krakow | Germanwings |
| | Warsaw | Brussels Airlines, Germanwings |
| Portugal |
| | Faro | Brussels Airlines, Germanwings |
| | Lisbon | Brussels Airlines |
| | Porto | Brussels Airlines |
| Republic of Ireland |
| | Dublin | Ryanair |
| Romania |
| | Bucharest | Germanwings |
| Russia |
| | Moscow | Brussels Airlines, Germanwings |
| Scotland |
| | Edinburgh | Brussels Airlines, Jet2 |
| Slovenia |
| | Ljubljana | Brussels Airlines |
| Spain |
| | Barcelona | Brussels Airlines, SmartWings, Vueling, Wizz Air |
| | Bilbao | Brussels Airlines |
| | Ibiza | SmartWings |
| | Las Palmas | SmartWings |
| | Madrid | Brussels Airlines, SmartWings, Wizz Air |
| | Malaga | Brussels Airlines, SmartWings |
| | Palma de Mallorca | Brussels Airlines, Germanwings, SmartWings |
| | Puerto de la Cruz | SmartWings |
| | Valencia | SmartWings |
| Sweden |
| | Gothenburg | Brussels Airlines |
| | Malmö | Wizz Air |
| | Norrköping | Cimber Sterling |
| | Stockholm | Brussels Airlines, Germanwings, Ryanair |
| Switzerland |
| | Geneva | Brussels Airlines |
| | Zürich | Germanwings |
| United Arab Emirates |
| | Dubai | Condor, SmartWings |
